Quasi-experimental study on Aloe Vera Gel As A Phytotherapy to Accelerate Perineal Wound Regeneration In Postpartum Mothers At Bpm Pera
Downloads
Perineal wounds are one of the most common complications in postpartum women, causing pain, increasing the risk of infection, and delaying recovery. The lack of effective, safe, affordable, and easily accessible therapies highlights a gap in perineal wound care practices, particularly in primary care. Aloe vera, which contains anti-inflammatory compounds and regenerative bioactives, has the potential to serve as an alternative phytotherapy, but clinical evidence of its effectiveness in perineal wounds remains limited. This study aimed to evaluate the effectiveness of aloe vera gel in accelerating perineal wound healing in postpartum women. The contribution of this research is to strengthen the practice of phytotherapy-based wound care that is safe, affordable, and applicable in primary health care facilities. The study used a quasi-experimental pre-post study design with a control group. Thirty postpartum women with grade I–II perineal wounds were divided into a treatment group (Aloe vera) and a control group (standard care). Healing was evaluated using the REEDA scale, and pain intensity was assessed using a Visual Analogue Scale (VAS) over seven days. Analysis was performed using an independent t-test with a significance level of 0.05. The results showed a significant difference between the two groups. The average healing time for the Aloe vera group was 4.20 days (SD 0.95), faster than the control group, which took an average of 7.00 days (SD 1.20). Statistical tests showed a p-value = 0.001, indicating significant effectiveness of Aloe vera application in accelerating tissue healing. In addition, REEDA and VAS scores on the seventh day were consistently lower in the treatment group, indicating a faster reduction in inflammation and pain. Implicitly, these findings provide a clinical contribution to strengthening safe and affordable phytotherapy-based wound care practices for postpartum mothers, particularly in primary healthcare facilities. This study concluded that aloe vera gel is an effective complementary therapy for accelerating perineal wound healing and improving maternal comfort.
[1] D. E. López Angulo and P. J. do Amaral Sobral, “Characterization of gelatin/chitosan scaffold blended with aloe vera and snail mucus for biomedical purpose,” Int. J. Biol. Macromol., vol. 92, 2016, doi: 10.1016/j.ijbiomac.2016.07.029.
[2] N. Chinchilla, C. Carrera, A. G. Durán, M. Macías, A. Torres, and F. A. Macías, “Aloe barbadensis: How a miraculous plant becomes reality,” Phytochemistry Reviews, vol. 12, no. 4. 2013. doi: 10.1007/s11101-013-9323-3.
[3] D. E. López Angulo, C. E. Ambrosio, R. Lourenço, N. J. Nardelli Gonçalves, F. S. Cury, and P. José do Amaral Sobral, “Fabrication, characterization and in vitro cell study of gelatin-chitosan scaffolds: New perspectives of use of aloe vera and snail mucus for soft tissue engineering,” Mater. Chem. Phys., vol. 234, 2019, doi: 10.1016/j.matchemphys.2019.06.003.
[4] WHO, Consolidated Guidelines on HIV, Viral Hepatitis and viral hepatitis and STI prevention, diagnosis, treatment and care for key populations. 2022.
[5] S. Singh, A. K. Gupta, and A. Verma, “Molecular properties and bioactivity score of the aloe vera antioxidant compounds - in order to lead finding,” Res. J. Pharm. Biol. Chem. Sci., vol. 4, no. 2, 2013.
[6] W. Pangesti and M. Murniati, “Penggunaan Kompres Aloevera untuk Menurunkan Suhu Tubuh Anak Demam: Case Study,” J. Manaj. Asuhan Keperawatan, vol. 7, no. 2, 2023, doi: 10.33655/mak.v7i2.172.
[7] W. Nugroho, “Relationship between environmental management policy and the local wisdom of indigenous peoples in the handling of covid-19 in indonesia,” Onati Socio-Legal Ser., vol. 11, no. 3, 2021, doi: 10.35295/OSLS.IISL/0000-0000-0000-1193.
[8] S. Qomariah, S. Herlina, and W. Sartika, “PENGARUH PEMAKAIAN BENGKUNG TERHADAP INVOLUSI UTERUS PADA IBU NIFAS DIWILAYAH KERJA PUSKESMAS SIAK HULU II,” JOMIS (Journal Midwifery Sci., vol. 8, no. 1, 2024, doi: 10.36341/jomis.v8i1.4060.
[9] N. Suprapto, B. K. Prahani, and T. H. Cheng, “Indonesian curriculum reform in policy and local wisdom: Perspectives from science education,” J. Pendidik. IPA Indones., vol. 10, no. 1, 2021, doi: 10.15294/jpii.v10i1.28438.
[10] H. Seif, A. Elbanna, A. M. Abu-Seida, and D. I. El-Korashy, “Regenerative potential of a novel aloe vera modified tricalcium silicate cement as a pulp capping material: An animal study,” Dent. Mater. J., vol. 42, no. 6, 2023, doi: 10.4012/dmj.2023-129.
[11] A. M. Hakim, “Efektifitas Aloe vera terhadap Luka Bakar,” J. Ilm. Kedokt. Wijaya Kusuma, vol. 9, no. 2, 2020, doi: 10.30742/jikw.v9i2.800.
[12] F. Ameen, S. L. Stephenson, S. AlNadhari, and M. A. Yassin, “Isolation, identification and bioactivity analysis of an endophytic fungus isolated from Aloe vera collected from Asir desert, Saudi Arabia,” Bioprocess Biosyst. Eng., vol. 44, no. 6, 2021, doi: 10.1007/s00449-020-02507-1.
[13] S. Tiwari, S. Prasad, and V. B. Upadhyay, “Bioactivity of Aloe vera Oil on the Weight and Length of Larvae of Silkworm (Bombyx mori Linn.),” Adv Biol Res, vol. 8, no. 1, 2014.
[14] H. Elaıbı, F. Mutlag, and Z. Kaream Al-Ebey, “A comprehensive review of Aloe vera: Multifaceted health benefits and anti-diabetic properties,” ~ 14 ~ J. Res. Chem., vol. 4, no. 2, 2023.
[15] H. D. Suresh, G. S. Nagananda, K. U. Minchitha, S. Swetha, and S. Suryan, “Synthesis and Bio-evaluation of Soluble Sodium Copper Chlorophyllin Complexes from the Leaves of Aloe vera,” South African J. Bot., vol. 147, 2022, doi: 10.1016/j.sajb.2021.11.055.
[16] M. A. S. E. Subroto, Kristyana Dananti, and Sri Wening, “Pemanfaatan Produk Pertanian yang Biodegradable pada Home Industry Pengolahan Aloe vera menjadi Nata de Aloevera,” J. Pengabdi. Masy. Akad., vol. 1, no. 2, 2023, doi: 10.59024/jpma.v1i2.178.
[17] S. Mani, G. Swargiary, S. Gulati, S. Gupta, and D. Jindal, “Molecular docking and ADMET studies to predict the anti-breast cancer effect of aloin by targeting estrogen and progesterone receptors,” Mater. Today Proc., vol. 80, 2023, doi: 10.1016/j.matpr.2021.06.362.
[18] I. Hiramatsu et al., “Tadalafil is sufficiently effective for patients with BPH together with severe CP/CPPS,” Neurourol. Urodyn., vol. 38, no. Supplement 3, 2019.
[19] S. S. Vasan, “Complications of Chronic Prostatitis,” Current Bladder Dysfunction Reports, vol. 7, no. 2. 2012. doi: 10.1007/s11884-012-0132-0.
[20] A. Femenia, P. García-Pascual, S. Simal, and C. Rosselló, “Effects of heat treatment and dehydration on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller,” Carbohydr. Polym., vol. 51, no. 4, 2003, doi: 10.1016/S0144-8617(02)00209-6.
[21] D. Maternity, “EFEKTIVITAS PENGGUNAAN LIDAH BUAYA (ALOEVERA) TERHADAP PENYEMBUHAN LUKA PERINEUM PADA IBU NIFAS DIWILAYAH KERJA PUSKEMAS KARANG ANYAR LAMPUNG SELATAN TAHUN 2021,” J. Ilm. Bidan, vol. 6, no. 2, 2022, doi: 10.61720/jib.v6i2.340.
[22] J. F. Solanilla-Duque et al., “Applications of Biodegradable Polymers in Food Industry,” in Biodegradable Polymers: Concepts and Applications, 2023. doi: 10.1201/9781003230533-13.
[23] Suyadi, Z. Nuryana, Sutrisno, and Baidi, “Academic reform and sustainability of Islamic higher education in Indonesia,” Int. J. Educ. Dev., vol. 89, p. 102534, 2022, doi: 10.1016/j.ijedudev.2021.102534.
[24] S. Asiimwe, A. Namutebi, A.-K. Borg-Karlsson, M. K. Mugisha, and H. Oryem-Origa, “Documentation and consensus of indigenous knowledge on medicinal plants used by the local communities of western Uganda,” J. Nat. Prod. Plant Resour, vol. 4, no. 1, 2014.
[25] J. U. Itelima, S. E. Agina, and S. G. Pandukur, “Antimicrobial activity of selected plant species and antibiotic drugs against Escherichia coli O157:H7,” African J. Microbiol. Res., vol. 11, no. 20, 2017, doi: 10.5897/ajmr2017.8440.
[26] A. O. Sadik and A. J. Carinci, “Acupuncture in the treatment of chronic pelvic pain,” in Acupuncture in Pain Management, 2014.
[27] F. P. Stangl et al., “Non-Antibiotic Prophylaxis for Recurrent UTIs in Neurogenic Lower Urinary Tract Dysfunction (NAPRUN): Study Protocol for a Prospective, Longitudinal Multi-Arm Observational Study,” Methods Protoc., vol. 6, no. 3, 2023, doi: 10.3390/mps6030052.
[28] C. I. Gamboa-Gómez, N. E. Rocha-Guzmán, M. R. Moreno-Jiménez, B. D. Vázquez-Cabral, and R. F. González-Laredo, “Plants with potential use on obesity and its complications,” EXCLI J., vol. 14, 2015, doi: 10.17179/excli2015-186.
[29] J. M. Nguta, R. Appiah-Opong, A. K. Nyarko, D. Yeboah-Manu, and P. G. A. Addo, “Medicinal plants used to treat TB in Ghana,” Int. J. Mycobacteriology, vol. 4, no. 2, 2015, doi: 10.1016/j.ijmyco.2015.02.003.
[30] K. Naik et al., “3D printable, injectable amyloid-based composite hydrogel of bovine serum albumin and aloe vera for rapid diabetic wound healing,” J. Mater. Chem. B, vol. 11, no. 34, 2023, doi: 10.1039/d3tb01151h.
[31] R. J. Van Barneveld et al., “Bone Health in Gynecologic Cancers-does FOSAVANCE Help?,” Am. J. Clin. Nutr., vol. 10, no. 1, 2019.
[32] M. Ranghoo-Sanmukhiya et al., “Molecular biology, phytochemistry and bioactivity of three endemic Aloe species from Mauritius and Réunion Islands,” Phytochem. Anal., vol. 21, no. 6, 2010, doi: 10.1002/pca.1234.
[33] A. Mootoosamy and M. Fawzi Mahomoodally, “Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius,” J. Ethnopharmacol., vol. 151, no. 1, 2014, doi: 10.1016/j.jep.2013.10.069.
[34] S. Agnes Mary and V. R. Giri Dev, “In vivo bioactivity of herbal-drug-incorporated nanofibrous matrixes,” J. Appl. Polym. Sci., vol. 132, no. 26, 2015, doi: 10.1002/app.42178.
[35] U. S. Harput, “Herbal products for oral hygiene: An overview of their biological activities,” in Natural Oral Care in Dental Therapy, 2020. doi: 10.1002/9781119618973.ch2.
[36] W. Majchrzak, I. Motyl, and K. Śmigielski, “Biological and Cosmetical Importance of Fermented Raw Materials: An Overview,” Molecules, vol. 27, no. 15. 2022. doi: 10.3390/molecules27154845.
Copyright (c) 2025 basaria, Retno Wahyuni, Hariati Eliana Purba, Isyos Sari Sembiring, Eva Ratna Dewi, Nopalina Suyanti Damanik, Titis Jernih Wati Gea (Author)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlikel 4.0 International (CC BY-SA 4.0) that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).






